Recent studies demonstrated that tumors overexpressing the epidermal growth factor receptor (EGF-R, erbB-1) are associated with poor clinical outcome. This led to the development of a variety of monoclonal antibodies targeting the extracellular domain of this receptor tyrosine kinase. The aim of our
β¦ LIBER β¦
Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy
β Scribed by E. Martinelli; R. De Palma; M. Orditura; F. De Vita; F. Ciardiello
- Book ID
- 108701084
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 317 KB
- Volume
- 158
- Category
- Article
- ISSN
- 0009-9104
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## Abstract A monoclonal antibody of the IgG class, EGFR1, has been isolated using cells of the epidermoid carcinoma line A431 as immunogen. The A431 antigen recognized by EGFR1 has an apparent molecular weight of approximately 175,000, is a cellβsurface molecule which can be specifically crossβlin
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