The conduct of phase I-II clinical trial
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Pratt, Charles B.
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Article
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1991
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John Wiley and Sons
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English
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Phase I Clinical Trials in children with cancer are carried out with therapeutic intent, so as to define antileukemic/antitumor activity, dose-limiting toxicity, maximum tolerated dosage, and pharmacokinetics. These studies define a dosage of an agent or combination that may be used in a larger stud