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Chalcone Arrests Cell Cycle Progression and Induces Apoptosis through Induction of Mitochondrial Pathway and Inhibition of Nuclear Factor Kappa B Signalling in Human Bladder Cancer Cells

✍ Scribed by Kun-Hung Shen; Jiunn-Kae Chang; Ya-Ling Hsu; Po-Lin Kuo

Book ID: 111316374
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 492 KB
Volume: 101
Category: Article
ISSN: 1742-7835
DOI: 10.1111/j.1742-7843.2007.00120.x

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## Abstract Overexpression of the interleukin‐2 receptor (IL‐2R) α chain in tumor cells is associated with tumor progression and a poor patient prognosis. IL‐2Rα is responsible for the high affinity binding of the receptor to IL‐2, leading to activation of several proliferative and anti‐apoptotic i