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(CH3As)2S2N4—A Novel Arsenic-Sulfur-Nitrogen Heterocycle

✍ Scribed by Prof. Dr. Otto J. Scherer; Dipl-Chem. Reinhard Wies

Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
249 KB
Volume
10
Category
Article
ISSN
0044-8249

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✦ Synopsis

freedom regarding choice of solvents, protective groups, and coupling method than peptide synthesis in solution.

Even the use of solid carriers having ordered surfaces ("brush carriers")l4~ ' I or uncrosslinked polystyrenesL6-*I cannot avoid these difficulties entirely.

We have now developed a synthesis in homogeneous phases which permits a definite and simple separation of reagents from the growing peptide chain. A solubilizing protective group is bound to the C-terminal amino acid where it remains for the duration of the synthesis. Polymeric protective groups can be chosen which make the molecule soluble in the desired solvents. In practice, polyethylene glycol residues which can form an ester-type bond with the Cterminal acid have proved particularly effective. The first amino acid as well as the following ones can be linked in homogeneous solution.

📜 SIMILAR VOLUMES

[Ph4P]2[Ni3N8S8], a Novel Trinuclear Com
[Ph4P]2[Ni3N8S8], a Novel Trinuclear Complex with Sulfur-Nitrogen Ligands
✍ Prof. Dr. Johannes Weiss 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB

Alkalis react with the violet, planar complex [Ni(HN,S,),] 1 to afford brown and red salts of the anions [Ni(HNzSz)(NzSz)]Q and [Ni(N2Sz)z]2Q 2, respectively"'. In turn, 2 can also act as a bidentate ligand in complexes. Thus with, e.g., Ni'@ the anion 3 is formed, a trinuclear complex in which two