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CG Dinucleotides of class II MHC genes are mutation hot-spots

✍ Scribed by Roberto Gambari; Roberta Piva; Stefano Volinia; Patrizia Orlando; Claudio Nastruzzi; Patrizio Giacomini; Pier Giorgio Natali; Rafaella Barbieri

Book ID: 104641304
Publisher: Springer
Year: 1988
Tongue: English
Weight: 693 KB
Volume: 1
Category: Article
ISSN: 0920-9069
DOI: 10.1007/bf00146813

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✦ Synopsis

DNA methylation of human class II genes of the Major Histocompatibility Complex (MHC) was correlated with gene expression and methyl-related CG --~ TG and CG --+ CA changes. It was found Uhat cytosine methylation of the CG dinucleotides of MHC class II genes should be involved in generating a fraction of nucleotide polymorphism, rather than in controlling transcription.

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