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Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines

✍ Scribed by Weiguang Wang; Elaina Collie-Duguid; James Cassidy

Book ID
117104833
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
216 KB
Volume
531
Category
Article
ISSN
0014-5793

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## Abstract 5‐Fluorouracil (5‐FU) is the major chemotherapeutic component for colorectal cancer (CRC) and other types of solid tumours. Resistance of cancer cells to 5‐FU is considered the major obstacle for successful chemotherapy. NF‐κB is a transcription factor. Cancer cells with high NF‐κB nucl