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Cerebrospinal fluid levels of nitric oxide metabolites predict response to methylprednisolone treatment in multiple sclerosis and optic neuritis

✍ Scribed by F. Sellebjerg; G. Giovannoni; A. Hand; H.O. Madsen; C.V. Jensen; P. Garred

Book ID
114137592
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
124 KB
Volume
125
Category
Article
ISSN
0165-5728

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Nitric oxide synthase is present in the
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Nitric oxide (NO) is hypothesized to play a role in the immunopathogenesis of multiple sclerosis (MS). Increased levels of NO metabolites have been found in patients with MS. Peroxynitrite, generated by the reaction of NO with superoxide at sites of inflammation, is a strong oxidant capable of damag

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## Abstract Predictors and laboratory correlates of the response of patients with multiple sclerosis to glucocorticoids are not well defined. Our study was undertaken to determine if the levels of myelin basic protein (MBP)‐like material in cerebrospinal fluid (CSF) might indicate which patients wi