✦ LIBER ✦

Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy

✍ Scribed by Jose Enrique Martinez-Rodriguez; Klaus Seppi; Adriana Cardozo; Alex Iranzo; Michaela Stampfer-Kountchev; Gregor Wenning; Eduardo Tolosa; Birgit Högl; Joan Santamaria; Werner Poewe

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 56 KB
Volume: 22
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.21668

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Hypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin‐1 levels in 15 patients with moderately severe multiple system atrophy (MSA), another synucleinopathy where sleep disorders occur frequently and EDS has been reported, performing additional electrophysiological studies in 5 of them to assess the presence of EDS and sleep onset REM (SOREM) periods. Despite relatively low sleep efficiencies in nocturnal sleep, mean sleep latencies in the Multiple Sleep Latency Test were normal with no SOREM periods. All patients had CSF hypocretin‐1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease. © 2007 Movement Disorder Society

📜 SIMILAR VOLUMES

Cerebrospinal fluid Aβ42 levels in multi

Cerebrospinal fluid Aβ42 levels in multiple system atrophy

✍ Marcel M. Verbeek; W. Farid Abdo; Danielle de Jong; Martin W.I.M. Horstink; Berr 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 57 KB

Reply: Cerebrospinal fluid Aβ42 levels i

Reply: Cerebrospinal fluid Aβ42 levels in multiple system atrophy

✍ Bjorn Holmberg 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 57 KB

## Abstract The letter to which this article refers can be found online: Mov Disord 2004;19(2):238–240.

Polyunsaturated fatty acid levels in the

Polyunsaturated fatty acid levels in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy

✍ Phil Hyu Lee; Gwang Lee; Man-Jeong Paik 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 67 KB 👁 1 views

Interleukin-2 levels in serum and cerebr

Interleukin-2 levels in serum and cerebrospinal fluid of multiple sclerosis patients

✍ P. Gallo; M. Piccinno; S. Pagni; Dr. B. Tavolato 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 298 KB 👁 2 views

Cerebrospinal fluid Aβ42 is reduced in m

Cerebrospinal fluid Aβ42 is reduced in multiple system atrophy but normal in Parkinson's disease and progressive supranuclear palsy

✍ Björn Holmberg; Bo Johnels; Kaj Blennow; Lars Rosengren 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 67 KB

## Abstract The 42‐amino–acid isoform of β‐amyloid Aβ42 in the cerebrospinal fluid (CSF) has recently been proposed as a biochemical marker for Alzheimer's disease (AD) and subcortical white‐matter dementia (SWD). In both of these conditions, concentration of CSF‐Aβ42 is reduced. We quantified CSF‐

Delineating the sites and progression of

Delineating the sites and progression of in vivo atrophy in multiple system atrophy using fluid-registered MRI

✍ Jonathan M. Schott; Jessica E. Simon; Nick C. Fox; Andrew P. King; M. Nadeem Kha 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 263 KB

## Abstract We describe the pattern and progression of atrophy delineated using fluid registration of serial magnetic resonance imaging scans in a case of multiple system atrophy (MSA). The in vivo findings were consistent with those found at postmortem, including significant supratentorial atrophy