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Cerebrospinal fluid brain specific proteins in relation to nitric oxide metabolites during relapse of multiple sclerosis

✍ Scribed by Rejdak, K.; Petzold, A.; Stelmasiak, Z.; Giovannoni, G.


Book ID
119946208
Publisher
SAGE Publications
Year
2008
Tongue
English
Weight
142 KB
Volume
14
Category
Article
ISSN
1352-4585

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Protein profile of cerebrospinal fluid i
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The leucocyte count, total protein, albumin, IgG, IgA and IgM content of the cerebrospinal fluid (CSF) of 103 multiple sclerosis (MS) patients was determined. In 54 cases a simultaneous analysis of serum was also carried out. As a sign of an intact blood brain barrier the albumin concentration was n

Nitric oxide synthase is present in the
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Nitric oxide (NO) is hypothesized to play a role in the immunopathogenesis of multiple sclerosis (MS). Increased levels of NO metabolites have been found in patients with MS. Peroxynitrite, generated by the reaction of NO with superoxide at sites of inflammation, is a strong oxidant capable of damag