Cerebrospinal fluid brain specific proteins in relation to nitric oxide metabolites during relapse of multiple sclerosis
β Scribed by Rejdak, K.; Petzold, A.; Stelmasiak, Z.; Giovannoni, G.
- Book ID
- 119946208
- Publisher
- SAGE Publications
- Year
- 2008
- Tongue
- English
- Weight
- 142 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1352-4585
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π SIMILAR VOLUMES
The leucocyte count, total protein, albumin, IgG, IgA and IgM content of the cerebrospinal fluid (CSF) of 103 multiple sclerosis (MS) patients was determined. In 54 cases a simultaneous analysis of serum was also carried out. As a sign of an intact blood brain barrier the albumin concentration was n
Nitric oxide (NO) is hypothesized to play a role in the immunopathogenesis of multiple sclerosis (MS). Increased levels of NO metabolites have been found in patients with MS. Peroxynitrite, generated by the reaction of NO with superoxide at sites of inflammation, is a strong oxidant capable of damag