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Cerebral Metabolism of 6–[18F]Fluoro-l-3,4-Dihydroxyphenylalanine in the Primate

✍ Scribed by G. Firnau; S. Sood; R. Chirakal; C. Nahmias; E. S. Garnett


Book ID
111174357
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
588 KB
Volume
48
Category
Article
ISSN
0022-3042

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We measured 6-[ 18 F]fluoro-L-DOPA (FDOPA) uptake and metabolism in the brain of 4-month-old female pigs (n ϭ 8) using a high-resolution positron emission tomograph (PET) in 3D mode. The mean net blood-brain clearance of FDOPA (K i D ) to striatum was 0.011 ml g -1 min -1 . Correcting for the elimin