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Comparative in vivo metabolism of 6-[18F]fluoro-l-DOPA and [3H]l-DOPA in rats

✍ Scribed by William P. Melega; André Luxen; Milton M. Perlmutter; Charna H.K. Nissenson; Michael E. Phelps; Jorge R. Barrio

Book ID
115781832
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
839 KB
Volume
39
Category
Article
ISSN
0006-2952

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✍ Gunter Firnau; E.S. Garnett; Raman Chirakal; Sudesh Sood; Claude Nahmias; Gary S 📂 Article 📅 1986 🏛 Elsevier Science ⚖ 457 KB

6-[18F]Fluoro-L-dopa was designed to trace the dopamine metabolism in the brain with positron tomography. 6-[18F]Fluoro-L-dopa resembles natural L-dopa biochemically, it crosses the blood-brain barrier with the similar kinetics, it is decarboxylated by dopa decarboxylase and is stored intraneuronall