Cerebral Ischemic Infarction in Paroxysmal Nocturnal Hemoglobinuria
โ Scribed by H. Audebert; J. Planck; M. Eisenburg; H. Schrezenmeier; R. L. Haberl
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 448 KB
- Volume
- 252
- Category
- Article
- ISSN
- 0340-5354
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A patient with paroxysmal nocturnal hemoglobinuria of 14 years duration presented with severe abdominal pain and fever. On admission, his hematocrit had fallen to 19% from his usual level of approximately 30%, and stools were positive for occult blood. Dilated loops of small bowel with air fluid lev
Paroxysmal nocturnal hemoglobinuria (PNH) hemolysis requires both intravascular complement activation and affected erythrocytes susceptible to complement. This susceptibility is explained by a deficiency in complement regulatory membrane proteins that are attached to the membrane by a glycosylphosph