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Cerebral Cortex: Neurodegenerative and Age-Related Changes in Structure and Function of Cerebral Cortex

✍ Scribed by Marilyn S. Albert, Mark B. Moss (auth.), Alan Peters, John H. Morrison (eds.)

Publisher
Springer US
Year
1999
Tongue
English
Leaves
799
Series
Cerebral Cortex 14
Edition
1
Category
Library
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✦ Synopsis

This volume of Cerebral Cortex is dedicated to Sir John Eccles, who was an active member of the advisory board for the series until his death in May 1997. His input as to what topics should be covered in future volumes of this series will be sorely missed. The present volume is concerned with neurodegenerative disorders and age­ related changes in the structure and function of the cerebral cortex, a topic that has attracted increasing interest as longevity and the number of aged individuals in the population increase. Although much of the research on the neurodegenerative effects of aging has been centered on Alzheimer's disease, most of the aging popu­ lation will not be afflicted by this disease. They will, however, be affected by the consequences of normal aging, so the first few chapters of this volume are con­ cerned with that topic. Chapter 1, by Marilyn S. Albert and Mark B. Moss, gives an account of the cognitive changes that accompany normal human aging. Chapter 2, by Mark B.

✦ Table of Contents

Front Matter....Pages i-xxvii
Cognitive Profiles of Normal Human Aging....Pages 1-20
Age-Related Cognitive Decline in the Rhesus Monkey....Pages 21-47
Normal Aging in the Cerebral Cortex of Primates....Pages 49-80
Age-Related Neuronal Loss in the Cerebral Cortex....Pages 81-88
Age-Related Cognitive Deficits and Neurotransmitters....Pages 89-110
Neurotransmitter Receptor Changes in the Hippocampus and Cerebral Cortex in Normal Aging....Pages 111-128
Trophic Factors in Experimental Models of Adult Central Nervous System Injury....Pages 129-173
Cortical Neuropathology in Aging and Dementing Disorders....Pages 175-311
The Anatomy of Dementias....Pages 313-364
Age-Related Changes in Subcortical Nuclei that Project to the Cerebral Cortex....Pages 365-397
Ultrastructural Changes in Dementing Illnesses....Pages 399-431
Locating Genetic Modifiers for Inherited Neurodegenerative Diseases....Pages 433-459
Early Features of Alzheimer’s Disease....Pages 461-474
Temporal Sequence of Alzheimer’s Disease-Related Pathology....Pages 475-512
Neuropathological Correlates of Dementia in Alzheimer’s Disease....Pages 513-551
Multifocal Cortical Neurodegeneration in Alzheimer’s Disease....Pages 553-601
Molecular Pathology of Alzheimer’s Disease and Related Disorders....Pages 603-654
Glutamate Receptors and Excitotoxic Mechanisms in Alzheimer’s Disease....Pages 655-679
Nerve Growth Factor Systems in Alzheimer’s Disease....Pages 681-731
Vascular-Related and Mediated Alterations in Alzheimer’s Disease....Pages 733-772
Back Matter....Pages 773-783

✦ Subjects

Neurology; Neurosciences; Anatomy

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