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Ceramide signaling in mammalian epidermis

✍ Scribed by Uchida, Yoshikazu

Book ID: 122828885
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 697 KB
Volume: 1841
Category: Article
ISSN: 1388-1981
DOI: 10.1016/j.bbalip.2013.09.003

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The sphingolipids la, b and 2a, b, which play important roles in epidermal barrier function, were synthesized by N-acylation of C,,-sphingosine 3 and I-0-glucosylated C,,-sphingosine 6, respectively, with w-acyloxy-substituted fatty acids 4 and 5 (Scheme 1 ) . These fatty acids were obtained from w-