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Ceramide induces apoptosis via CPP32 activation

✍ Scribed by Noboru Mizushima; Ryuji Koike; Hitoshi Kohsaka; Yasunori Kushi; Shizuo Handa; Hideo Yagita; Nobuyuki Miyasaka

Book ID
115932969
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
402 KB
Volume
395
Category
Article
ISSN
0014-5793

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Members of the interleukin-1b-converting enzyme (ICE)/CED-3 protease family have been implicated in apoptosis in both vertebrates and invertebrates. Using primary culture methods, we report that neurons and astrocytes require the activity of the ICE/CED-3 family of proteases to undergo apoptosis ind