Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
β Scribed by Cungui Mao; Lina M. Obeid
- Book ID
- 116273305
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 910 KB
- Volume
- 1781
- Category
- Article
- ISSN
- 1388-1981
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π SIMILAR VOLUMES
A novel regioselective synthesis of D-erythro -sphingosine 1-phosphate and D-erythro -ceramide 1-phosphate is described. The synthesis is based upon (1) in situ oxidative phosphorylation of the primary hydroxyl group in N-Boc-D-erythro-sphingosine utilizing trimethyl phosphite and carbon tetrabromid
## Abstract Readily available Dβ__erythro__βazidosphingosine is transformed into 3β__O__βsilylβprotected derivative 6. Reduction of the azido group afforded 3β__O__βsilylβprotected sphingosine 7 which was either converted into __N__βFmocβprotected derivative 8 or via Nβacylation into ceramide deriv