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Centrosomes and myeloma; Aneuploidy and proliferation

โœ Scribed by Wee J. Chng; Rafael Fonseca


Book ID
102186961
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
160 KB
Volume
50
Category
Article
ISSN
0893-6692

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Centrosome amplification and aneuploidy
โœ William G. Kearns; Hiroki Yamaguchi; Neal S. Young; Johnson M. Liu ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 117 KB

## Abstract Patients with bone marrow failure are at risk for development of hematopoietic progenitor clones with abnormal numbers of chromosomes (aneuploidy) and leukemia. Numerical centrosome abnormalities or mutations in genes associated with the mitotic spindle checkpoint (__BUB1__ and __MAD2__