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Centromeres in cell division, evolution, nuclear organization and disease

✍ Scribed by Amanda Gonçalves dos Santos Silva; Rahul Sarkar; Jana Harizanova; Amanda Guffei; Michael Mowat; Yuval Garini; Sabine Mai

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
374 KB
Volume
104
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three‐dimensional organization of centromeres in normal and tumor cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division. J. Cell. Biochem. 104: 2040–2058, 2008. © 2008 Wiley‐Liss, Inc.

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