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Cellular Regulation of Hemoglobin Switching: Evidence for Inverse Relationship between Fetal Hemoglobin Synthesis and Degree of Maturity of Human Erythroid Cells

✍ Scribed by Thalia Papayannopoulou, Themistoklis Kalmantis and George Stamatoyannopoulos

Book ID: 123656027
Publisher: National Academy of Sciences
Year: 1979
Tongue: English
Weight: 992 KB
Volume: 76
Category: Article
ISSN: 0027-8424
DOI: 10.2307/70252

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DNA-synthesis state of circulating burst forming unit-erythroid (BFU-E) was evaluated in patients with sickle cell anemia and correlated with percent of fetal hemoglobin synthesized in the BFU-E-derived cells. Percentage of S-phase BFU-E inversely correlated with percent fetal hemoglobin synthesized