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Cellular pharmacokinetics and pharmacodynamics of the deoxycytidine analog 2′-C-cyano-2′-deoxy-1-β-d-arabino-pentofuranosylcytosine (CNDAC)

✍ Scribed by Atsushi Azuma; Peng Huang; Akira Matsuda; Williamm Plunkett


Book ID
113992655
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
366 KB
Volume
61
Category
Article
ISSN
0006-2952

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Antitumor activity and novel DNA-self-st
✍ Kenji Hanaoka; Masako Suzuki; Tomowo Kobayashi; Fumie Tanzawa; Kazuo Tanaka; Tak 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 221 KB

We have studied the antitumor activity and the novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-Ccyano-2-deoxy-␤-D-arabino-pentofuranosyl)cytosine) and its N 4 -palmitoyl derivative (CS-682). In vitro, CS-682 showed strong cytotoxicity against human tumor cells comparable with that of CNDAC;