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Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

✍ Scribed by Trottier, Yvon; Devys, Didier; Imbert, Georges; Saudou, Frédéric; An, Isabelle; Lutz, Yves; Weber, Chantal; Agid, Yves; Hirsch, Etienne C.; Mandel, Jean-Louis

Book ID
109915973
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
1018 KB
Volume
10
Category
Article
ISSN
1061-4036

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## Abstract Huntington's disease is one of the several neurodegenerative diseases caused by dominant mutations that expand the number of glutamine codons within an existing poly‐glutamine (polyQ) repeat sequence of a gene. An expanded polyQ sequence in the huntingtin gene is known to cause the hunt