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Cellular insulin resistance decreases osmotic shock-induced glucose transport in 3T3-L1 adipocytes

✍ Scribed by Andrej Janez; Dorothy Sears-Worrall; Jerrold M Olefsky


Book ID
117370092
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
148 KB
Volume
50
Category
Article
ISSN
0168-8227

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## Abstract We used nigericin, a K^+^/H^+^ exchanger, to test whether glucose transport in 3T3‐L1 adipocytes was modulated by changes in intracellular pH. Our results showed that nigericin increased basal but decreased insulin‐stimulated glucose uptake in a time‐ and dose‐dependent manner. Whereas