Cellular Inhibition of Protein Tyrosine Phosphatase 1B by Uncharged Thioxothiazolidinone Derivatives
✍ Scribed by Matthew Stuible; Liang Zhao; Isabelle Aubry; Dirk Schmidt-Arras; Frank-D. Böhmer; Chao-Jun Li; Michel L. Tremblay
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 308 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1439-4227
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Synthesis and Biological Evaluation of α,α-Difluorobenzylphosphonic Acid Derivatives as Small Molecular Inhibitors of Protein-Tyrosine Phosphatase 1B. -Title compounds (V) and (XI) are prepared by a Stille coupling reaction sequence. It is shown that desired inhibitory activity towards protein-tyro