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Cellular basis for age-related differences in cardiac excitation–contraction coupling

✍ Scribed by Michael Artman; Gillian Henry; William A Coetzee

Book ID: 114343909
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 140 KB
Volume: 11
Category: Article
ISSN: 1058-9813
DOI: 10.1016/s1058-9813(00)00049-7

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## Abstract Intracellular Na^+^ concentration ([Na^+^]~i~) is very important in modulating the contractile and electrical activity of the heart. Upon electrical excitation of the myocardium, voltage‐dependent Na^+^ channels open, triggering the upstroke of the action potential (AP). During the AP,