## Abstract We studied the restoration of doxorubicin accumulation and sensitivity by verapamil and quinine in a variant of the human erythroleukemia cell line K562 selected for resistance to doxorubicin and presenting a multidrug‐resistance (MDR) phenotype. Verapamil was able to completely restore
Cellular and karyotypic characterization of two doxorubicin resistant cell lines isolated from the same parental human leukemia cell line
✍ Scribed by John R. Zalcberg; Xiu F. Hu; Dominic M. Wall; Shelagh Mirski; Susan Cole; Gabrielle Nadalin; Mario de Luise; John D. Parkin; Vickie Vrazas; Lynda Campbell; Phillip Kantharidis
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 1013 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0020-7136
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## Abstract HL‐60‐R, a multi‐drug‐resistant (MDR) subclone of the human leukemia cell line HL‐60, was selected in continuous culture in doxorubicin (DOX) in the absence of mutagenic agents. When compared to the parent line HL‐60, HL‐60‐R showed greater relative resistance to vinblastine than to eto