Cell type-specific activation of the cytomegalovirus promoter by dimethylsulfoxide and 5-Aza-2′-deoxycytidine
✍ Scribed by Prakash Radhakrishnan; Hesham Basma; David Klinkebiel; Judith Christman; Pi-Wan Cheng
- Book ID
- 116307562
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 1015 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1357-2725
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## Abstract In gastric cancer, increasing numbers of genes have been reported to be silenced by aberrant methylation. However, global analysis of epigenetic inactivation in cancer cells has rarely been performed. For screening the genes upregulated by the demethylating agent 5‐aza‐2′‐deoxycytidine
We have previously demonstrated cells. These Hox proteins are shown to synergistically that a short sequence element (L7ATE) within the activate the L7 promoter by cotransfection assay in proximal promoter of a Purkinje cell-specific gene, pcp-2(L7), is required for the normal pattern of exvitro. In