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Cell Transplantation in Surgical Treatment of Familial Adenomatous Polyposis Coli

✍ Scribed by G. I. Vorobyov; A. M. Kuzminov; D. V. Vyshegorodtsev; L. L. Kapuller; G. T. Sukhikh


Publisher
Springer US
Year
2011
Tongue
English
Weight
388 KB
Volume
150
Category
Article
ISSN
0007-4888

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## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with

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## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm