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Cell-specific expression of the glucose-dependent insulinotropic polypeptide gene functions through a PDX-1 motif in a mouse neuroendocrine tumor cell line

✍ Scribed by Lisa I. Jepeal; Michael O. Boylan; M. Michael Wolfe

Book ID
119429471
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
192 KB
Volume
120
Category
Article
ISSN
0016-5085

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Embryonic stem (ES) cells can be differentiated into insulin-producing cells by conditioning the culture media. However, the number of insulin-expressing cells and amount of insulin released is very low. Glucose-dependent insulinotropic polypeptide (GIP) enhances the growth and differentiation of pa