Cell signalling and the control of pre-mRNA splicing
β Scribed by Shin, Chanseok; Manley, James L.
- Book ID
- 109958211
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 218 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1471-0072
- DOI
- 10.1038/nrm1467
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This book was written for graduate and medical students, as well as clinicians and postdoctoral researchers. It describes the theory of alternative pre-mRNA splicing in twelve introductory chapters and then introduces protocols and their theoretical background relevant for experimental research. The
Nuclear pre-mRNAs must be precisely processed to give rise to mature cytoplasmic mRNAs. This maturation process, known as splicing, involves excision of intron sequences and ligation of the exon sequences. One of the major problems in understanding this process is how splice sites, the sequences whi