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Cell repair after liver injury: Stimulation of RNA synthesis, engaged polymerases, number of RNA transcribing molecules, and elongation rate in postischemic liver nuclei

✍ Scribed by G. Cairo; Luisa Schiaffonati; A. Bernelli-Zazzera

Book ID
113147218
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
1023 KB
Volume
35
Category
Article
ISSN
0014-4800

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Nuclei isolated from ischemic liver show a consistent reduction of their RNA synthesis. The reduction persists at high ionic strength and in the presence of heparin, when RNA synthesis in vitro is fully activated and occurs in the presence as well as in the absence of alpha-amanitin. Both the number

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## Abstract Nuclei isolated from liver cells recovering from reversible (non‐necrogenic) ischemia show an increased RNA synthesis. The postischemic effect is not abolished by previous adrenalectomy and occurs in fasted as well as in fed animals. Treatment with cycloheximide, at a dose that severely