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RNA synthesis and number of transcribing polymerase molecules in ischemic liver nuclei

✍ Scribed by L. Schiaffonati; G. Cairo; A. Bernelli-Zazzera

Publisher
Springer
Year
1991
Tongue
English
Weight
375 KB
Volume
48
Category
Article
ISSN
0300-8177

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✦ Synopsis

Nuclei isolated from ischemic liver show a consistent reduction of their RNA synthesis. The reduction persists at high ionic strength and in the presence of heparin, when RNA synthesis in vitro is fully activated and occurs in the presence as well as in the absence of alpha-amanitin. Both the number of transcribing polymerase molecules and the rate of elongation of initiated polynucleotide chains seem to be equally affected.

πŸ“œ SIMILAR VOLUMES

Cell repair after liver injury: An analy
Cell repair after liver injury: An analysis of some metabolic conditions required for the stimulation of RNA synthesis in postischemic liver nuclei
✍ Roberta Piccoletti; Aldo Bernelli-Zazzera πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 English βš– 679 KB

## Abstract Nuclei isolated from liver cells recovering from reversible (non‐necrogenic) ischemia show an increased RNA synthesis. The postischemic effect is not abolished by previous adrenalectomy and occurs in fasted as well as in fed animals. Treatment with cycloheximide, at a dose that severely