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Cell proliferation and vascularization in human breast carcinomas

✍ Scribed by F. Monschke; W.-U. Müller; U. Winkler; C. Streffer

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
476 KB
Volume
49
Category
Article
ISSN
0020-7136

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✦ Synopsis

Cell proliferation and vascularization were studied in I0 human breast carcinomas by an immunoenzyme technique. The monoclonal antibody (MAb) Ki-67 was used as a marker for proliferating cells and a polyclonal antibody directed against human von-Willebrand factor to identify blood vessels. The proportion of Ki-67-labelled cells varied from I% to 20%, the number of small blood vessels from 4.4/mm2 to 57.6/mm2. Within single histological sections of individual turnours the percentage of proliferating cells was not related to the number of small blood vessels. However, after evaluation of 5 sections of each tumour, the average values showed that tumours with a high grade of vascularization had a higher percentage of Ki-67-positive cells than poorly vascularized samples. The influence of vascular density on cell proliferation was investigated in a selected area of one of the tumours (in 2-dimensions) and with regard to the over-and underlying sections (in 3-dimensions). After 2-dimensional evaluation, distances from proliferating cells to the closest blood vessel between 10 and 390 krn were observed, and after 3-dimensional evaluation none of the proliferating cells measured was located more than I30 pm away from the closest vessel.

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