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Cell morphology, proliferation and collagen synthesis of human fibroblasts cultured on sepiolite-collagen complexes

✍ Scribed by Olmo, Nieves ;Lizarbe, Maria A. ;Turnay, Javier ;Müller, Klaus P. ;Gavilanes, José G.

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
793 KB
Volume
22
Category
Article
ISSN
0021-9304

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✦ Synopsis

Madrid, Spnin. ~Max-Planck-IrzsfrtiAt fur B i o ~l i m i i r , 1)-81133 Mnrfrnsried bei Miinchen, Federal Xepliblir of Germany

The growth and morphology as well as collagen biosynthesis of human fibroblasts obtained and cultured on sepiolite-collagen complexes have been studied. No differences on cell morphology and growth properties nor collagen synthesis were observed when compared with standard culture substrates. The type I/type 111 ratio of biosynthesized collagen by fibroblasts cul-tured on sepiolite-collagen complexes was about 5-6 with no difference when compared to control conditions. This normal behavior was also observed for the type I/ type 111 procollagens. According to these studies the sepiolite-collagen complexes do not modify the studied features of the fibroblasts.

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