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Cell-mediated cytotoxic islet cell surface antibodies to human pancreatic beta cells

✍ Scribed by T. Maruyama; I. Takei; I. Matsuba; A. Tsuruoka; M. Taniyama; Y. Ikeda; K. Kataoka; M. Abe; S. Matsuki

Publisher
Springer
Year
1984
Tongue
English
Weight
381 KB
Volume
26
Category
Article
ISSN
0012-186X

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✦ Synopsis

Sera containing islet cell surface antibodies show a complement-dependent cytotoxic reaction against islet cells, but it has not yet been clarified whether islet cell surface antibodies exhibit cell-mediated cytotoxicity to these cells. By 51Cr release assay we investigated whether islet cell surface antibodies showed a cytotoxic reaction to human pancreatic B cells (JHPI-1 clone) in the presence of normal human lymphocytes. The sera from 14 islet cell surface antibody-positive, 16 islet cell surface antibody-negative Type 1 (insulin-dependent) diabetic patients and 18 islet cell surface antibody-negative healthy subjects were studied. Four sera containing islet cell surface antibodies showed specific cytotoxicity above the mean +3SD value of healthy subjects, and the mean specific cytotoxicity of islet cell surface antibody-positive sera differed significantly from that of both islet cell surface antibody-negative groups. These results suggest that this cell-mediated cytotoxic mechanism may play an important role in the pathogenesis of Type 1 diabetes.

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