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Cell lines with spontaneous secretion of pregnancy-associated α2-globulin

✍ Scribed by E. Lundgren; M. G. Damber; G. Roos; B. von Schoultz; T. Stigbrand; K. Nilsson; J. J. Alexander

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
335 KB
Volume
24
Category
Article
ISSN
0020-7136

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✦ Synopsis

Pregnancy-associated alpha 2-globulin (PA alpha 2G) was quantitated by radioimmunoassay in culture media from 34 exponentially growing human cell lines. Only 8/34 cell lines produced PA alpha 2G. The highest secretion was found in cell lines of histiocytic lymphoma origin while it was low in some carcinoma-derived lines. The results may support an assumption that PA alpha 2G is a normal cell product of B-lymphoid, monocytic and epithelial cells but may also simply indicate that ectopic PA alpha 2G production is especially common in tumors derived from such cells. The availability of PA alpha 2G-producing cell lines should facilitate studies of the immunoregulatory role of this protein.

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