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Cell-free activation of a DNA-binding protein by epidermal growth factor

✍ Scribed by Sadowski, Henry B.; Gilman, Michael Z.


Book ID
109783453
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
661 KB
Volume
362
Category
Article
ISSN
0028-0836

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## Abstract We found that caffeine significantly inhibited epidermal growth factor (EGF)‐ and 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA)‐induced cell transformation in the JB6 mouse epidermal cell line. The tumor promoter‐induced cell transformation was also blocked by treatment with an adenosi