Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation

Transforming growth factor-β1-dependent

Transforming growth factor-β1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells

✍ Kiyoshi Wakahara; Hiroshi Kobayashi; Tatsuo Yagyu; Hidenori Matsuzaki; Toshiharu 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 617 KB

## Abstract The net balance between urokinase‐type plasminogen activator (uPA) and plasminogen activator inhibitor type‐1 (PAI‐1) has been implicated in tumor cell invasion and metastasis. To elucidate the mechanism of the transforming growth factor‐β1 (TGF‐β1)‐dependent up‐regulation of PAI‐1 expr