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Cell death in rheumatoid arthritis

✍ Scribed by Adelheid Korb; Hermann Pavenstädt; Thomas Pap

Publisher
Springer
Year
2009
Tongue
English
Weight
250 KB
Volume
14
Category
Article
ISSN
1360-8185

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The programmed death 1/programmed death
The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis
✍ Amalia P. Raptopoulou; George Bertsias; Dimitrios Makrygiannakis; Panagiotis Ver 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 607 KB

## Abstract ## Objective T cells play a major role in the pathogenesis of rheumatoid arthritis (RA). The programmed death 1 (PD‐1)/programmed death ligand 1 (PDL‐1) pathway is involved in peripheral tolerance through inhibition of T cells at the level of synovial tissue. The aim of this study was