Polymorphisms of Genes for Programmed Cell Death 1 Ligands in Patients with Rheumatoid Arthritis
โ Scribed by Shu-Chen Wang; Chia-Hui Lin; Ruei-Nian Li; Tsan-Teng Ou; Cheng-Chin Wu; Wen-Chan Tsai; Hong-Wen Liu; Jeng-Hsien Yen
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 115 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0271-9142
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## Abstract ## Objective. The expression of autoimmunity in mice deficient in programmed death 1 (PDโ1) suggests that PDโ1 is a candidate gene involved in the development of human autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). We therefore tested the
## Abstract ## Objective T cells play a major role in the pathogenesis of rheumatoid arthritis (RA). The programmed death 1 (PDโ1)/programmed death ligand 1 (PDLโ1) pathway is involved in peripheral tolerance through inhibition of T cells at the level of synovial tissue. The aim of this study was