Cell Death in Retinitis Pigmentosa: Gap Junctions and the ‘Bystander’ Effect
✍ Scribed by Harris Ripps
- Book ID
- 115605869
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 194 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0014-4835
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## Abstract Retinitis pigmentosa (RP) is a heterogeneous group of diseases in which one of a wide variety of mutations selectively causes rod photoreceptor cell death. After rods die, cone photoreceptors gradually die resulting in blindness. Antioxidants reduce cone cell death in __rd1__/__rd1__ mi
## Abstract Retinitis pigmentosa (RP) is a prevalent cause of blindness caused by a large number of different mutations in many different genes. The mutations result in rod photoreceptor cell death, but it is unknown why cones die. In this study, we tested the hypothesis that cones die from oxidati
## Abstract It is controversially discussed that irradiation induces bystander effects via gap junction channels and/or diffusible cellular factors such as nitric oxide or cytokines excreted from the cells into the environment. But up to now the molecular mechanism leading to a bystander response i