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Cell-cycle regulation of the p53-inducible gene B99

✍ Scribed by Licio Collavin; Martin Monte; Roberto Verardo; Cathie Pfleger; Claudio Schneider


Book ID
117102236
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
261 KB
Volume
481
Category
Article
ISSN
0014-5793

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Activation of the tumor suppressor protein p53 can lead to arrest in both G 1 and G 2 stages of the cell cycle and, in some cells, to apoptotic cell death. In this study, we showed that the p53 response to a chemotherapeutic drug, actinomycin D, was reversible in both normal and tumor cells, even wh