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Cell cycle phase specificity of hydroxyurea and its effects on the cell kinetics in embryonic spinal cord

✍ Scribed by Herken, R.

Book ID
112216967
Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
663 KB
Volume
21
Category
Article
ISSN
0040-3709

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## Abstract ## Background: DNA replication stress often induces DNA damage. The antitumor drug hydroxyurea (HU), a potent inhibitor of ribonucleotide reductase that halts DNA replication through its effects on cellular deoxynucleotide pools, was shown to damage DNA inducing double‐strand breaks (D