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Cell cycle perturbating agents in a line of human thyroid transformed cells in culture (HuT)

✍ Scribed by Aldo Mancini; Maria Rosaria Faraone-Mennella; Piera Quesada; Maria Malanga; Benedetta Farinai

Book ID: 104672703
Publisher: Springer
Year: 1991
Tongue: English
Weight: 617 KB
Volume: 103
Category: Article
ISSN: 0300-8177
DOI: 10.1007/bf00227483

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✦ Synopsis

Culture and differentiation parameters of a human thyroid transformed cell line (HuT) were analyzed. Treatment with high concentrations of chemical agents namely dimethyl sulphoxide and retinoic acid, exerted a dramatic cytotoxic effect. The exposure of these cells to the lowest doses of retinoic acid as well as to 8 mM-16 mM 3-aminobenzamide a potent inhibitor of poly(ADPribose)polymerase, resulted in a delay of cell proliferation. Poly(ADPribose)polymerase activity was differently affected by retinoic acid (stimulation) and 3-aminobenzamide (inhibition).

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