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Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315

✍ Scribed by Fogal, Valentina; Hsieh, Jung-Kuang; Royer, Christophe; Zhong, Shan; Lu, Xin


Book ID
110031128
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
553 KB
Volume
24
Category
Article
ISSN
0261-4189

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## Abstract The tumor‐suppressor p53 is a multifunctional protein mainly responsible for maintaining genomic integrity. p53 induces its tumor‐suppressor activity by either causing cell‐cycle arrest (G~1~/S or G~2~/M) or inducing cells to undergo apoptosis. This function of wild‐type p53 as “guardia