Our understanding of the process by which eukaryotes regulate initiation of DNA replication has made remarkable advances in the past few years, thanks in large part to the explosion of genetic and biochemical information on the budding yeast, Saccharomyces cerevisiae. At least three major concepts h
Cell cycle control of initiation of eukaryotic DNA replication
โ Scribed by Joel A. Huberman
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 614 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0009-5915
No coin nor oath required. For personal study only.
โฆ Synopsis
models are available to explain the limitation of DNA synthesis to a single round per S phase without requiring the participation of cis-acting negative control elements;
(5) candidates for eukaryotic replication-origin-binding proteins have been identified.
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absolutely unfailing way. This problem is largely ignored in traditional studies on eukaryotic DNA replication. ## Summary A hypothesis for the control of eukaryotic DNA replication at the chromosomal level is proposed. The specific regulatory problem arises from the subdivision of the genome int