✦ LIBER ✦

Initiation of eukaryotic DNA replication in vitro

✍ Scribed by Bruce Stillman

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 723 KB
Volume: 9
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950090205

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✦ Synopsis

Recent advances in our understanding of the mechanism and regulation of eukaryotic DNA replication have been expedited by the use of cell-free systems capable of initiation of DNA replication. The system capable of replicating plasmid DNAs containing the SV40 origin of DNA replication in vitro is a paradigm fur studies on the replication of other virus DNAs and the replication of cellular chromosomes. This review outlines some of the contemporary issues and developments related to this complex problem.

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