Cell cycle control of activated, synchronized murine B lymphocytes—roles of macrophages and complement C3
✍ Scribed by Fritz Melchers; Anna Erdei; Catherine Corbel; Maria Leptin; Thomas Schulz; Manfred P. Dierich
- Book ID
- 119089638
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 436 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0161-5890
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Complement is an essential innate immune mechanism that recognizes and eradicates microbes and associated toxins. In addition, complement receptors (CD21 and CD35) on B cells cooperate with the B-cell antigen receptor (BCR) to efficiently recognize and respond to antigens bearing complement C3d(g).
The third component of complement C3 has been implied in the stimulation of B lymphocytes to proliferation and maturation for Ig secretion. We have reinvestigated the extent of this activation with either activated or resting murine splenic lymphocytes in serum-substituted cultures. Human C3 was use