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Cell cycle alterations and the inhibition of humanpancreatic cell replication by opioid growth factor

✍ Scribed by Zagon, Ian S.; Smith, Jill P.; Roesener, Colleen D.; Verderame, Michael F.; McLaughlin, Patricia J.


Book ID
122645159
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
179 KB
Volume
118
Category
Article
ISSN
0016-5085

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## Abstract We have recently found that aphidicolin, a tetracyclic diterpene‐tetraol produced by several fungi, blocks DNA synthesis of sea urchin embryos by interfering with the activity of DNA polymerase Ξ±. These cells fail to proliferate in the presence of aphidicolin. In continuation of these