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Cell-context specific role of the E2F/Rb pathway in development and disease

✍ Scribed by Victoria A. Swiss; Patrizia Casaccia

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
592 KB
Volume
58
Category
Article
ISSN
0894-1491

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✦ Synopsis

Abstract

Development of the central nervous system (CNS) requires the generation of neuronal and glial cell subtypes in appropriate numbers, and this demands the careful coordination of cell‐cycle exit, survival, and differentiation. The E2F/Rb pathway is critical for cell‐cycle regulation and also modulates survival and differentiation of distinct cell types in the developing and adult CNS. In this review, we first present the specific temporal patterns of expression of the E2F and Rb family members during CNS development and then discuss the genetic ablation of single or multiple members of these two families. Overall, the available data suggest a time‐dependent and cell‐context specific role of E2F and Rb family members in the developing and adult CNS. © 2009 Wiley‐Liss, Inc.

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