✦ LIBER ✦

Cell based therapy for duchenne muscular dystrophy

✍ Scribed by Andrea Farini; Paola Razini; Silvia Erratico; Yvan Torrente; Mirella Meregalli

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 159 KB
Volume: 221
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21895

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Mutations in the dystrophin gene cause an X‐linked genetic disorder: Duchenne muscular dystrophy (DMD). Stem cell therapy is an attractive method to treat DMD because a small number of cells are required to obtain a therapeutic effect. Here, we discussed about multiple types of myogenic stem cells and their possible use to treat DMD. The identification of a stem cell population providing efficient muscle regeneration is critical for the progression of cell therapy for DMD. We speculated that the most promising possibility for the treatment of DMD is a combination of different approaches, such as gene and stem cell therapy. J. Cell. Physiol. 221: 526–534, 2009. © 2009 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

The IVth workshop on Duchenne muscular d

The IVth workshop on Duchenne muscular dystrophy gene therapy

✍ K. Schwartz; F. Leterrier 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 68 KB 👁 1 views

Gene therapy for duchenne dystrophy

✍ Andrew G. Engel 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 240 KB 👁 1 views

Topiramate for weight reduction in duche

Topiramate for weight reduction in duchenne muscular dystrophy

✍ Gregory T. Carter; Michelle P. Yudkowsky; Jay J. Han; Megan A. McCrory 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 38 KB

miRNAs as serum biomarkers for Duchenne

miRNAs as serum biomarkers for Duchenne muscular dystrophy

✍ Davide Cacchiarelli; Ivano Legnini; Julie Martone; Valentina Cazzella; Adele D'A 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 713 KB

Dystrophin absence in Duchenne muscular dystrophy (DMD) causes severe muscle degeneration. We describe that, as consequence of fibre damage, specific muscle-miRNAs are released into the bloodstream of DMD patients and their levels correlate with the severity of the disease. The same miRNAs are abund

Exercise and duchenne muscular dystrophy

Exercise and duchenne muscular dystrophy: Toward evidence-based exercise prescription

✍ Chad D. Markert; Fabrisia Ambrosio; Jarrod A. Call; Robert W. Grange 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB

Theoretical expectations for deletional

Theoretical expectations for deletional mutations in duchenne muscular dystrophy

✍ Grimm, Tiemo ;Danieli, Gian A. ;Muller, Clemens R. ;Neri, Giovanni ;Reynolds, Ja 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 327 KB 👁 1 views

## To the Editor: In a population, when equilibrium between mutation and selection is reached, a fraction (x) of individuals affected by an X-linked recessive lethal disorder is due to new mutations [Haldane, 19351. Being p, the mutation rate in female germ cells, and v, the mutation rate in male